I just read an article at Science Daily about a study by a team of international researchers, led by Antonio Naranjo of the University of Las Palmas de Gran Canaria, Spain, and colleagues in Argentina, Europe, and the USA have analyzed data from the QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) study.on the subject of patients who have been prescribed certain prescription drugs for their rheumatoid arthritis.
They have been found to have a reduced risk of heart attacks: “Taking methotrexate — the most widely used DMARD — for just one year for example was found to be associated with an 18% reduction in risk of heart attack and an 11% decrease in risk of stroke, the researchers say”. “Rheumatoid arthritis is a known risk factor for hardening of the arteries and so can lead to stroke and heart attacks occurring in sufferers ten years earlier than in people without the condition”.
“Our study provides further support of the influence of both traditional and RA specific risk factors in the development of cardiovascular events, especially heart attack” the researchers conclude, “As assessed by this study, the risk was lower with the prolonged use of methotrexate, sulfasalazine, glucocorticoids, leflunomide and TNF-± blockers.”
It is important to keep in mind at all times when reading research studies that most if not all researchers are funded by pharmaceutical companies. So do you realy think they would tell you the rest of the possible effects these drugs may have on you health??? Unfortunately they don’t, OK, so you have less risk of heart attack or stroke, but please read the following information taken from MedlinePlus drug database:
One of the drugs they recommend you to take long term to avoid cardiovascular problems is Methotrexoate, MedlinePlus has this warning about this drug :
“Methotrexate may cause very serious side effects. Some side effects of methotrexate may cause death. You should only use methotrexate to treat life-threatening cancer, or certain other conditions that are very severe and that cannot be treated with other medications. Methotrexate may cause liver damage, Methotrexate may cause lung damage, Methotrexate may cause kidney damage, Methotrexate may cause a decrease in the number of blood cells made by your bone marrow.Methotrexate may cause damage to your intestines, Methotrexate may cause a severe rash that may be life-threatening. Methotrexate may decrease the activity of your immune system, and you may develop serious infections. Taking methotrexate may increase the risk that you will develop lymphoma (cancer that begins in the cells of the immune system). If you do develop lymphoma, it might go away without treatment when you stop taking methotrexate, or it might need to be treated with chemotherapy”. Phew, no mention of a heart attack here!
Glocorticoids: ” Elevated pressure in the eyes ( glaucoma), fluid retention causing swelling in the lower legs, increased blood pressure, mood swings, weight gain with fatty deposits in the abdomen, neck, and face (moonface). Cataracts, high blood sugar which can trigger or worsen diabetes, increased risk of infections, loss of calcium from bones which can lead to osteoporosis and fractures. Menstrual irregularities, suppressed adrenal gland hormone production, thin skin, easy bruising, and slower wound healing”. No mention of possible heart attack as a side effect.
The anti tumor necrosis drugs one of which is Infliximab “may decrease your ability to fight infection and increase the risk that you will get a serious or life-threatening infection. Tell your doctor if you have any type of infection now, including minor infections (such as open cuts or sores), infections that come and go (such as cold sores) and chronic infections that do not go away, or if you often get any type of infection such as bladder infections. Also tell your doctor if you are taking medications that suppress the immune system such as azathioprine (Imuran), cancer chemotherapy medications, cyclosporine (Neoral, Sandimmune), oral corticosteroids; 6-mercaptopurine (Purinethol); methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus (Prograf). If you experience any of the following symptoms during or shortly after your treatment with infliximab, call your doctor immediately: sore throat; cough; fever; extreme tiredness; flu-like symptoms; warm, red, or painful skin; or other signs of infection”.
“Infliximab increases the risk that you will get some types of infections that are most common in certain parts of the United States and the world. Tell your doctor all the places you previously lived and all the places you recently visited or plan to visit while using infliximab”.
“You may be infected with tuberculosis (TB, a type of lung infection) but not have any symptoms of the disease. In this case, infliximab may increase the risk that your infection will become more serious and you will develop symptoms. Your doctor will perform a skin test to see if you have an inactive TB infection. If necessary, your doctor will give you medication to treat this infection before you start using infliximab. Tell your doctor if you have or have ever had TB, or if you have been around someone who has TB”.
As for the other drugs that are on the list of recommendations: Eflunomide, sulfasalazine these drugs may produce these side effects: diarrhea, headache , loss of appetite, upset stomach, vomiting, stomach pain, skin rash, itching, hives, swelling, sore throat, fever, joint or muscle aches, pale or yellow skin, difficulty swallowing, tiredness, unusual bleeding or bruising, weakness, hair loss, dizziness, runny nose, urinary tract infection, back pain, mouth sores, flu-like symptoms, difficulty breathing, chest pain, and increased heart rate.
Judging from all of the foregoing possible side effects, one can only think that the reason the subjects in the study didn’t die from a heart attack or stroke was because they didn’t live long enough to experience one. Their already compromised immune systems couldn’t cope with the deleterious toxic effects of the drugs they were taking, and they died from causes other than cardiovascular disease.
The study doesn’t report that the subjects in the study went on to lead long and productive lives, all that’s reported is that the incidence of heart attacks and strokes is reduced. Would this be lying by omission? Caveat emptor.
References:
ScienceDaily (Mar. 7, 2008)
MedlinePlus Drug Database.
*Journal reference: Cardiovascular disease in patients with rheumatoid arthritis. Results from the QUEST-RA study Antonio Naranjo, Tuulikki Sokka, Miguel A Descalzo, Jaime Calvo-Alen, Kim Horslev-Petersen, Reijo K Luukkainen, Bernard Combe, Gerd R Burmester, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann-Carin Holmqvist, Ernest Choy, Recep Tunc, Aleksander Dimic, Martin Bergman, Sergio Toloza and Theodore Pincus. Arthritis Research & Therapy (in press) http://arthritis-research.com/content/10/2/R30